British medical journal slams Roche on Tamiflu

LONDON (AP) — A leading British medical journal is asking the drug maker Roche to release all its data on Tamiflu, claiming there is no evidence the drug can actually stop the flu.

The drug has been stockpiled by dozens of governments worldwide in case of a global flu outbreak and was widely used during the 2009 swine flu pandemic.

On Monday, one of the researchers linked to the BMJ journal called for European governments to sue Roche.

"I suggest we boycott Roche's products until they publish missing Tamiflu data," wrote Peter Gotzsche, leader of the Nordic Cochrane Centre in Copenhagen. He said governments should take legal action against Roche to get the money back that was "needlessly" spent on stockpiling Tamiflu.

Last year, Tamiflu was included in a list of "essential medicines" by the World Health Organization, a list that often prompts governments or donor agencies to buy the drug.

Tamiflu is used to treat both seasonal flu and new flu viruses like bird flu or swine flu. WHO spokesman Gregory Hartl said the agency had enough proof to warrant its use for unusual influenza viruses, like bird flu.

"We do have substantive evidence it can stop or hinder progression to severe disease like pneumonia," he said.

In the U.S., the Centers for Disease Control and Prevention recommends Tamiflu as one of two medications for treating regular flu. The other is GlaxoSmithKline's Relenza. The CDC says such antivirals can shorten the duration of symptoms and reduce the risk of complications and hospitalization.

In 2009, the BMJ and researchers at the Nordic Cochrane Centre asked Roche to make all its Tamiflu data available. At the time, Cochrane Centre scientists were commissioned by Britain to evaluate flu drugs. They found no proof that Tamiflu reduced the number of complications in people with influenza.

"Despite a public promise to release (internal company reports) for each (Tamiflu) trial...Roche has stonewalled," BMJ editor Fiona Godlee wrote in an editorial last month.

In a statement, Roche said it had complied with all legal requirements on publishing data and provided Gotzsche and his colleagues with 3,200 pages of information to answer their questions.

"Roche has made full clinical study data ... available to national health authorities according to their various requirements, so they can conduct their own analyses," the company said.

Roche says it doesn't usually release patient-level data available due to legal or confidentiality constraints. It said it did not provide the requested data to the scientists because they refused to sign a confidentiality agreement.

Roche is also being investigated by the European Medicines Agency for not properly reporting side effects, including possible deaths, for 19 drugs including Tamiflu that were used in about 80,000 patients in the U.S.

____

Online:

www.bmj.com.tamiflu/

Read More..

'Inappropriate’ emails, ‘shirtless’ photos

Gen. David Petraeus and Paula Broadwell in July 2011 (ISAF via Getty Images)It seemed the story behind Gen. David Petraeus' resignation as director of the CIA couldn't get stranger. New reports, however, now indicate that Marine Gen. John Allen, another well-respected, high-ranking general, might be involved in the growing scandal.


On the surface, the case so far involves the FBI; a slew of allegedly inappropriate emails (between Petraeus and his biographer, Paula Broadwell; Allen and socialite Jill Kelley; and allegedly threatening ones Broadwell sent to Kelley); the FBI agent who started the probe, who's now being investigated for sending "shirtless" photos to Kelley; and, as reported by the New York Post on Tuesday morning, a child custody battle involving Kelley's twin sister that allegedly concerns both Petraeus and Allen.


To help sort things out, here's a rundown of events, and where things currently stand.


Jill Kelley, a 37-year-old from Tampa, Fla., who organized local social events for the military as a volunteer, became friends with Petraeus and his family when he was stationed in Florida. Last spring, she began receiving harassing emails from an anonymous account and alerted a friend who worked for the FBI.


The FBI began an investigation, which eventually uncovered an affair between Petraeus and Broadwell, both of whom are married. The FBI believes Broadwell sent the harassing emails to Kelley because she perceived her to be a rival for Petraeus' affections.


The FBI found something else during the inquiry: 20,000 to 30,000 pages of emails and other communications between Kelley and Allen, the top commander in Afghanistan and a nominee to become the new NATO supreme allied commander for Europe.


A senior defense official has told the Washington Post that the emails were "potentially inappropriate." Other sources strongly denied to the Post that anything inappropriate ever happened between Allen and Kelley, but said that Allen may have used terms of endearment such as "sweetheart" to refer to Kelley in his emails to her. The source said Allen, who is married, is "embarrassed" by this, but did not have an affair with her. Allen also received an email from the same account that was harassing Kelley, though it's unclear what the email said.


Both Petraeus and Allen also wrote letters submitted to a court on behalf of Kelley's twin sister, who was locked in a nasty custody fight with the father of her 4-year-old child. The generals vouched for the sister's abilities as a mother, the Post reported.


The Tampa party planner, who is married and has three children, is also at the center of another bizarre twist in the case. The Wall Street Journal reported on Monday night that Kelley's FBI agent friend was taken off the Petraeus case and is currently being investigated because his superiors discovered that he sent "shirtless" photos to Kelley before the probe started. After the agent was removed from the case, the agent contacted Washington Rep. David Reichert to warn him that he thought FBI leaders would sweep the investigation under the rug.


Meanwhile, the Daily Beast, citing an anonymous source, reports that the harassing emails allegedly sent from Broadwell to Kelley did not say "stay away from my guy" as previously reported, and did not even directly reference Petraeus. The source described the tone of the emails as "more like, 'Who do you think you are? You parade around the base. You need to take it down a notch.'" The Wall Street Journal reported that one email, without elaborating, asked Kelley if her husband knew what she was doing. Another said the sender knew Kelley had touched "him," without specifying who the "him" was.


And, the Associated Press has uncovered the trick Broadwell and Petraeus used to email each other without creating an online trail. The pair set up anonymous email accounts and drafted emails to each other without ever pushing "send." Each one could log on to the other account and click the "drafts" folder to see if a message had been left for them. This avoids creating an easily traceable email trail, the AP reported.


One question the Daily Beast raised is why the FBI investigated the harassing emails sent to Kelley in the first place. There were no overt threats, such as "I'll kill you," in the emails, and some wonder if Kelley's friendship with the FBI agent may be why the agency investigated what seemed like a humdrum case better suited to local authorities.


Broadwell's father, for one, told the New York Daily News that he thinks the scandal is a smoke screen for a bigger story. "This is about something else entirely, and the truth will come out," Broadwell's father, Paul Krantz, told the Daily News. "There is a lot more that is going to come out."


Read More..

China slams Dalai Lama; Tibetan self-immolates

BEIJING (AP) — China accused the Dalai Lama on Monday of allying with Japanese right-wingers in an island dispute as a way of attacking China and blamed him for glorifying a wave of self-immolations among Tibetans. The comments came as another Tibetan set himself on fire to protest Chinese rule, Tibetan exiles and a rights group said.

Chinese Foreign Ministry spokesman Hong Lei said the Dalai Lama's comments in Japan on the island dispute showed his "reactionary nature" and determination to split China apart under the guise of religion.

"To achieve his separatist goal, he associated with the Japanese right-wing forces. Chinese people despise him for what he did. We are firmly opposed to any country's providing a stage for him," Hong said.

Chinese media have said the Dalai Lama called the islands by their Japanese name during a news conference in Yokohama last Monday but an Associated Press review of a tape of the event showed he referred to them only as "the islands."

On Monday in Okinawa, the Dalai Lama criticized Chinese media for making up a claim that he sided with the Japanese.

Tensions have run high over the islands, known as Senkaku in Japanese and Diaoyu in Chinese, since the Japanese government nationalized some of them in September in a bid to prevent Tokyo's right-wing governor from buying them. Violent anti-Japanese protests broke out in a number of Chinese cities, and Beijing has sent ships to conduct near-constant patrols near the uninhabited rocks.

Hong also attacked the Dalai Lama for reportedly accusing the Chinese government of failing to investigate the root cause of despair and hopelessness among Tibetans that many say have prompted people to take their lives as a form of protest. China has long accused the Dalai Lama and his supporters of inspiring such acts, despite his condemnation of all forms of violence.

"Not only did the Dalai not condemn them, but he actually glorified these acts, which are against the national law and religious principles," Hong said.

The remarks came as a 24-year-old Tibetan man set himself on fire at a prayer ceremony in Tongren county in western China's Qinghai province, becoming the seventh person in six days to self-immolate in the region, the rights group Free Tibet said.

Nyingkar Tashi is reported to have died in the protest in which he called out for freedom in Tibet and for the longevity of the Dalai Lama, the group said. A statement from the self-declared Tibetan government-in-exile in Dharmsala, India, provided similar details.

A Tongren government official who picked up the phone said he could not comment, while Ma Chunyin, head of the Tongren Communist Party Propaganda Department, said he did not know about the reported self-immolation.

Tibet support groups overseas have said the increase in protests in recent days is meant to highlight Tibetan unhappiness with Chinese rule as the country's leaders hand over power to younger successors at a party congress in Beijing.

"Throughout the 18th Party Congress the new unelected leaders have been reminded on an almost daily basis of Tibetans' rejection of Chinese rule, and of the terrible failure of policies to cement the occupation," Free Tibet Director Stephanie Brigden said.

The Dalai Lama fled to India following an abortive 1959 uprising against Chinese rule over Tibet. He denies seeking the region's independence, saying that he wishes Tibetans to enjoy real autonomy and protection of their traditional Buddhist culture.

___

Associated Press writers Christopher Bodeen in Beijing and Mari Yamaguchi in Tokyo contributed to this report.

Read More..

Dutch teenagers sentenced in “Facebook murder”
















AMSTERDAM (Reuters) – Two Dutch teenagers were sentenced to two years in juvenile detention and three years of compulsory therapy on Monday for ordering the death of a girl after an argument on Facebook.


The case, known in the Netherlands as the “Facebook murder”, has caused widespread debate about the role of social media in violent crime.













The victim, identified only as 15-year old Winsie, was fatally stabbed in January at the request of the boy and girl, who were aged 17 and 16 respectively at the time.


Winsie had argued for weeks with the girl, and they had swapped insults on the social networking site.


“The defendants are guilty of a particularly serious criminal offence. The fact that a friendship between two young girls can turn into deep hate and ultimately into murder being incited is shocking and hard to comprehend,” a court in the city of Arnhem said in a statement.


The killer, who Dutch media named only as Jinhua and who was 14 when he committed the crime, was sentenced in September to one year in juvenile detention.


(Reporting Gilbert Kreijger; Editing by Anthony Deutsch and Pravin Char)


Internet News Headlines – Yahoo! News



Read More..

Elmo puppeteer accused of underage relationship

NEW YORK (AP) — The puppeteer who performs as Elmo on "Sesame Street" is taking a leave of absence from the popular kids' show in the wake of allegations that he had a relationship with a 16-year-old boy.

Sesame Workshop said puppeteer Kevin Clash denies the charges, which were first made in June by the alleged partner, who by then was 23.

"We took the allegation very seriously and took immediate action," Sesame Workshop said in a statement issued Monday. "We met with the accuser twice and had repeated communications with him. We met with Kevin, who denied the accusation."

The organization described the relationship as personal and "unrelated to the workplace." Its investigation found the allegation of underage conduct to be unsubstantiated. But it said Clash exercised "poor judgment" and was disciplined for violating company policy regarding Internet usage. It offered no details.

"I had a relationship with (the accuser)," Clash told TMZ. "It was between two consenting adults and I am deeply saddened that he is trying to make it into something it was not."

At his request, Clash has been granted a leave of absence in order to "protect his reputation," Sesame Workshop said.

No further explanation was provided, nor was the duration of his leave specified.

"Elmo is bigger than any one person and will continue to be an integral part of 'Sesame Street' to engage, educate and inspire children around the world, as it has for 40 years," Sesame Workshop said in its statement.

"Sesame Street" is currently in production, but other puppeteers are prepared to fill in for Clash during his absence, according to a person close to the show who spoke on condition of anonymity because that person was not authorized to publicly discuss details about the show's production.

"Elmo will still be a part of the shows being produced," that person said.

The 52-year-old Clash, the divorced father of a grown daughter, has been a puppeteer for "Sesame Street" since 1984. It was then that he was handed the fuzzy red puppet named Elmo and asked to come up with a voice for him. Clash transformed the character, which had been a marginal member of the Muppets troupe for a number of years, into a major star rivaling Big Bird as the face of "Sesame Street."

In 2006, Clash published an autobiography, "My Life as a Furry Red Monster," and was the subject of the 2011 documentary "Being Elmo: A Puppeteer's Journey."

Read More..

British medical journal slams Roche on Tamiflu

LONDON (AP) — A leading British medical journal is asking the drug maker Roche to release all its data on Tamiflu, claiming there is no evidence the drug can actually stop the flu.

The drug has been stockpiled by dozens of governments worldwide in case of a global flu outbreak and was widely used during the 2009 swine flu pandemic.

On Monday, one of the researchers linked to the BMJ journal called for European governments to sue Roche.

"I suggest we boycott Roche's products until they publish missing Tamiflu data," wrote Peter Gotzsche, leader of the Nordic Cochrane Centre in Copenhagen. He said governments should take legal action against Roche to get the money back that was "needlessly" spent on stockpiling Tamiflu.

Last year, Tamiflu was included in a list of "essential medicines" by the World Health Organization, a list that often prompts governments or donor agencies to buy the drug.

Tamiflu is used to treat both seasonal flu and new flu viruses like bird flu or swine flu. WHO spokesman Gregory Hartl said the agency had enough proof to warrant its use for unusual influenza viruses, like bird flu.

"We do have substantive evidence it can stop or hinder progression to severe disease like pneumonia," he said.

In the U.S., the Centers for Disease Control and Prevention recommends Tamiflu as one of two medications for treating regular flu. The other is GlaxoSmithKline's Relenza. The CDC says such antivirals can shorten the duration of symptoms and reduce the risk of complications and hospitalization.

In 2009, the BMJ and researchers at the Nordic Cochrane Centre asked Roche to make all its Tamiflu data available. At the time, Cochrane Centre scientists were commissioned by Britain to evaluate flu drugs. They found no proof that Tamiflu reduced the number of complications in people with influenza.

"Despite a public promise to release (internal company reports) for each (Tamiflu) trial...Roche has stonewalled," BMJ editor Fiona Godlee wrote in an editorial last month.

In a statement, Roche said it had complied with all legal requirements on publishing data and provided Gotzsche and his colleagues with 3,200 pages of information to answer their questions.

"Roche has made full clinical study data ... available to national health authorities according to their various requirements, so they can conduct their own analyses," the company said.

Roche says it doesn't usually release patient-level data available due to legal or confidentiality constraints. It said it did not provide the requested data to the scientists because they refused to sign a confidentiality agreement.

Roche is also being investigated by the European Medicines Agency for not properly reporting side effects, including possible deaths, for 19 drugs including Tamiflu that were used in about 80,000 patients in the U.S.

____

Online:

www.bmj.com.tamiflu/

Read More..

Petraeus' aide wondered about Broadwell's behavior, qualifications


Retired Gen. David Petraeus, who resigned as CIA director last week after admitting an extramarital relationship, could possibly face military prosecution for adultery if officials turn up any evidence to counter his apparent claims that the affair began after he left the military.


The affair between Petraeus and his biographer, Paula Broadwell, both of whom are married, began several months after his retirement from the Army in August 2011 and ended four months ago, retired U.S. Army Col. Steve Boylan, a former Petraeus spokesman, told ABC News.


Broadwell, 40, had extraordinary access to the 60-year-old general during six trips she took to Afghanistan as his official biographer, a plum assignment for a novice writer.


"For him to allow the very first biography to be written about him, to be written by someone who had never written a book before, seemed very odd to me," former Petraeus aide Peter Mansoor told ABC News.


The timeline of the relationship, according to Patraeus, would mean that he was carrying on the affair for the majority of his tenure at the CIA, where he began as director Sept. 6, 2011. If he carried on the affair while serving in the Army, however, Patraeus could face charges, according to Article 134 of the Uniform Code of Military Justice, which reprimands conduct "of a nature to bring discredit upon the armed forces."


Whether the military would pursue such action, whatever evidence it accumulates, is unclear.


As the details of the investigation launched by the FBI unraveled this weekend, it became clear that the woman at the heart of the inquiry that led to Petraeus' downfall had been identified as Jill Kelley, a Florida woman who volunteers to help the military. She is a family friend of Petraeus, who Broadwell apparently felt threatened by.


Kelley and her husband are longtime supporters of the military, and six months ago she was named "Honorary Ambassador to Central Command" for her volunteer work with the military. Officials say Kelley is not romantically linked to Petraeus, but befriended the general and his wife when he was stationed in Florida. The Kelleys spent Christmases in group settings with the Petraeuses and visited them in Washington D.C., where Kelley's sister and her son live.


"We and our family have been friends with Gen. Petraeus and his family for over five years." Kelley said in a statement Sunday. "We respect his and his family's privacy and want the same for us and our three children."


Earlier this year, around the time that Petraeus and Broadwell were breaking off their affair, Kelly began receiving anonymous emails, which she found so threatening she went to authorities. The FBI traced the messages to Broadwell's computer, where they found other salacious and explicit emails between Broadwell and Petraeus that made it clear to officials that the two were carrying on an affair.


Investigators uncovered no compromising of classified information or criminal activity, sources familiar with the probe said, adding that all that was found was a lot of "human drama."




Broadwell, a married mother of two, had access to Petraeus while she was with him in Afghanistan as his official biographer. People close to the general had previously suspected Broadwell's feelings for him had crossed a professional line.


They found Broadwell, who spent a year embedded with Petraeus in Afghanistan, to be embarrassing and far too "gushy" about him. They said to one another they thought Broadwell "was in love with him," sources told ABC News.


Petraeus is said to have been the one to have broken off the extramarital affair.


His storied career, first as the public face of two wars in Iraq and Afghanistan, and later as director of the CIA, came crashing down Friday when he announced his resignation from the intelligence agency, citing the indiscretion.


"After being married for over 37 years, I showed extremely poor judgment by engaging in an extramarital affair. Such behavior is unacceptable, both as a husband and as the leader of an organization such as ours," Petraeus said in a statement Friday.


Director of National Intelligence James Clapper was made aware of the Petraeus situation Tuesday evening around 5 p.m. by the FBI, according to a senior intelligence source.


After having several conversations with Petraeus that evening and the next day, Clapper advised Petraeus that the best thing to do would be for him to resign, the source said.


Clapper notified the White House the next afternoon that Petraeus was considering resigning, according to the source. Petraeus then went to the White House Thursday and told the president he thought he should resign, and Obama accepted his resignation the next day, the source said.


Despite the lengthy investigation into Broadwell by the FBI, the White House says it was not made aware of it until Wednesday, the day after the election, a revelation that surprised many.


"It just doesn't add up. That the FBI would be carrying on this type of investigation without, again, bringing it to the president or the highest levels of the White House," Rep. Peter King, R-N.Y., said.


Petraeus and his wife, Holly, who have been married for 38 years, are said to be staying in their Arlington Home and are doing "OK."


"Knowing the family, I suspect it will be hard work, but given the effort, they will get through it," Boylan, the former Petraeus spokesman, said.


Numerous questions still remain about the investigation, and some on Capitol Hill are also frustrated because Petraeus was schedule to testify to the House and Senate intelligence committees about the attack on the U.S. consulate in Benghazi, Libya, in September.


The timing of Petraeus' resignation "was what it was," an official told ABC News, adding that the time had come to tie up any loose ends in the investigation and confront the general.

Also Read
Read More..

Man in Afghan uniform kills foreign service member

KABUL, Afghanistan (AP) — A gunman wearing an Afghan army uniform on Sunday shot and killed a member of the U.S.-led coalition forces fighting in Afghanistan — the latest in a spate of insider attacks that are fracturing the trust between NATO and Afghan forces.

Separately, officials said 11 Afghan civilians were killed by land mines on Sunday in explosions in the east and south.

U.S. Army Maj. Martyn Crighton, a spokesman for the coalition, said the service member was killed in the south. His identity and nationality were not disclosed.

Mohammad Zarak, spokesman for the governor of Helmand province, said the shooting took place in Nad Ali district after an argument between an Afghan soldier and coalition service members.

Coalition figures show at least 60 coalition service members have been killed so far this year and others have been wounded in about 45 insider attacks, where members of the Afghan security forces or insurgents dressed in their uniforms turn their guns on U.S. and allied troops.

The insider attacks have raised questions about how effectively the allied forces can train the Afghans to take over security of their own country in 2014 and beyond. Foreign forces are due to turn over security responsibility to the local military by the end of 2014.

A roadside bomb killed three men, two women and a baby in Khost province of eastern Afghanistan, deputy provincial police chief Youqib Khan said. He said their vehicle hit the bomb as they were returning from a hospital.

Three other civilians were killed when their vehicle detonated a land mine on the road between Helmand and Kandahar provinces, a government statement said.

Also in the south, two civilians who were walking were killed by a land mine in Khakrez district of Kandahar province, said Ahmad Jawed Faisal, a spokesman for the provincial governor.

The United Nations says homemade bombs continue to be the weapons that kill the most civilians in the war.

___

Associated Press Writers Rahim Faiez and Mirwais Khan contributed to this report.

Read More..

Ohio teen sentenced to life in Craigslist murders
















AKRON, Ohio (Reuters) – Seventeen-year-old Brogan Rafferty was sentenced to life in prison without parole on Friday for his role in the killing of three men and the attempted murder of another, some of whom were lured by a Craigslist ad promising work on an Ohio farm.


Rafferty was 16 when he was arrested in November 2011, but was tried as an adult. He was convicted late last month in the murders of David Pauley, 51, of Norfolk, Virginia; Ralph Geiger, 56, of Akron, Ohio; and Timothy Kern, 47, of Massillon, Ohio.













Prosecutors called the teen an apt pupil to the alleged trigger-man, Richard Beasley, 53, who is also charged in the murders.


Rafferty testified that he was terrified of the man he had considered a father figure and spiritual advisor after he saw Beasley shoot Geiger in the head execution-style.


During the trial, jurors heard testimony that the teen helped dig the graves for three of the men and was found in possession of guns and knives stolen from them after Beasley shot them.


Beasley’s trial is scheduled in the same courtroom for January 7. He faces the death penalty if convicted. Both Rafferty and Beasley’s attorneys are under a gag order and are not permitted to talk to the media.


In other incidents involving Craigslist and other social media, people advertising goods for sale or responding to ads have been attacked and killed.


In 2009, a former medical student was accused of killing a masseuse he met through Craigslist. In February, two men in Tennessee were accused of killing a man and a woman for “unfriending” the daughter of one of the suspects on Facebook.


(Reporting by Kim Palmer; Editing by Mary Wisniewski and David Brunnstrom)


Internet News Headlines – Yahoo! News



Read More..

Bond soars with record $87.8M 'Skyfall' debut

LOS ANGELES (AP) — The sky's the limit for James Bond's "Skyfall."

The 23rd Bond film hauled in a franchise-record $87.8 million in its first weekend at U.S. theaters.

According to distributor Sony, adding $2.2 million from Thursday night previews at large-format theaters, "Skyfall" has taken in $90 million domestically.

That lifts the worldwide total for "Skyfall" to around half a billion dollars once its weekend haul is counted overseas, where the film began rolling out in late October. As of last Thursday, "Skyfall" had rung up nearly $350 million internationally.

The third installment starring Daniel Craig as British super-spy Bond, "Skyfall" outdid the $67.5 million U.S. debut of 2008's "Quantum of Solace," the franchise's previous best opening.

"Skyfall" more than doubled the $40.8 million debut of Craig's first Bond film, 2006's "Casino Royale."

Read More..